Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors
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چکیده
منابع مشابه
Effects of p38 MAP kinase inhibitors on the differentiation and maturation of erythroid progenitors.
In rodents, p38 MAP kinase inhibitors (p38is) induce bone marrow hypocellularity and reduce reticulocyte and erythrocyte counts. To identify target cell populations affected, a differentiating primary liquid erythroid culture system using sca-1(+)cells from mouse bone marrow was developed and challenged with p38is SB-203580, SB-226882, and SB-267030. Drug-related alterations in genes involved a...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2008
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623308327121